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Thursday, March 28, 2024

NIST Publishes Review of DNA Mixture Interpretation Methods

The National Institute of Standards and Technology (NIST) has published DNA Mixture Interpretation: A Scientific Foundation Review. This draft report, which will be open for public comment for 60 days before being published in final form, reviews the methods that forensic laboratories use to interpret evidence containing a mixture of DNA from two or more people.

NIST scientific foundation reviews document and evaluate the scientific basis for forensic methods. These reviews fill a need identified in a landmark 2009 study by the National Academy of Sciences, which found that many forensic disciplines lack a solid foundation in scientific research.

The NIST review states that currently “there is not enough publicly available data to enable an external and independent assessment of the degree of reliability of DNA mixture interpretation practices, including the use of probabilistic genotyping software (PGS) systems.”

PGS systems are used to perform complex statistical calculations when interpreting DNA mixtures. The report reviewed those systems as well as the larger workflows in which they are used.

The review identified many peer-reviewed studies of PGS systems, but most did not include the type of detailed data that would allow for an independent assessment of system performance. Forensic laboratories conduct internal studies to test their own systems, but most do not make the resulting data publicly available, partly out of privacy concerns surrounding the genetic data used in those studies.

The report specifies the types of data that would enable an independent assessment and shows how statistical methods could be used to assess performance if that data were available. The report also recommends that researchers and forensic laboratories publish this data in a way that will allow results from different studies to be more easily compared.

DNA profiling generally produces very reliable results when the evidence contains sufficient DNA from a single individual. The NIST report only addresses DNA mixtures, which can present much greater challenges.

Those challenges have increased in recent years with advancing technology. When DNA methods were first developed in the 1980s, labs needed the amount of DNA found in a dime-sized blood or semen stain to produce a genetic fingerprint. Today, they can get a genetic fingerprint from the “touch DNA” that a person leaves behind when handling doorknobs, firearms and other objects.

This increased sensitivity makes DNA useful for investigating a greater variety of crimes. But highly sensitive techniques often pick up mixtures of DNA from multiple people, some of whom may have had nothing to do with the crime being investigated.

“Estimating how many individuals contributed to a DNA mixture, distinguishing one person’s DNA from another and determining if the DNA is even relevant to the crime can be very challenging,” said NIST Fellow and lead author John Butler. “If not properly considered and communicated, these issues can lead to misunderstandings regarding the strength and relevance of the DNA evidence in a case.”

Read more at NIST

NIST Publishes Review of DNA Mixture Interpretation Methods Homeland Security Today
Homeland Security Today
The Government Technology & Services Coalition's Homeland Security Today (HSToday) is the premier news and information resource for the homeland security community, dedicated to elevating the discussions and insights that can support a safe and secure nation. A non-profit magazine and media platform, HSToday provides readers with the whole story, placing facts and comments in context to inform debate and drive realistic solutions to some of the nation’s most vexing security challenges.
Homeland Security Today
Homeland Security Todayhttp://www.hstoday.us
The Government Technology & Services Coalition's Homeland Security Today (HSToday) is the premier news and information resource for the homeland security community, dedicated to elevating the discussions and insights that can support a safe and secure nation. A non-profit magazine and media platform, HSToday provides readers with the whole story, placing facts and comments in context to inform debate and drive realistic solutions to some of the nation’s most vexing security challenges.

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