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Sunday, March 3, 2024

Bridge the Knowledge-to-Action Gap to Fight the Next Outbreak Now

COVID-19 is not the first global pandemic and it certainly won’t be the last. As the light at the end of the tunnel of this pandemic is in sight, now is the time to take stock in what we’ve learned over the last 12 months – namely, that effective response depends on timely integration of expertise and data across academia, industry, and government. As a national laboratory, we have participated in the establishment of dynamic R&D-to-operations teams that support this integration. The goal is to steward these capabilities to enable an efficient and effective response to the next event.

This unifying goal is the focus of the recently released COVID-19 strategy, which focuses on developing centers such as the National Center for Epidemic Forecasting and Outbreak Analytics. To support these efforts, the community must bridge the gap between the operational entities that deploy resources and the supporting science and research entities that innovate. The pandemic offers a case study for events of national significance where operational response must incorporate leading-edge scientific information.

For any disease outbreak, there are two well-understood sides of the response. The first is research and development, which looks closely at the disease to determine its origins, how it spreads, effective pharmaceutical and non-pharmaceutical interventions, etc. The second is operational, which includes determining and communicating decisions, distributing test kits, personal protective equipment, and vaccines, etc. But there is an important part of the scientific response between these two pieces that is often overlooked: evaluation and translation to actionable knowledge and market-ready products.

Many groups independently rallied around the COVID-19 response effort to answer these urgent needs. Universities and industry intensified collaborations for vaccine research.  The fashion world turned warehouses into mask-production sites. The automotive industry retooled sites to make face shields. And the Department of Energy put the technical power of the national laboratories to work as an integrated National Virtual Biotechnology Laboratory through funding from the CARES Act to impact manufacturing, epidemiological planning, testing, and molecular therapeutic R&D.

At Los Alamos National Laboratory, when COVID-19 broke out, we were called on to answer difficult science questions: from the efficacy of different testing methods, to how aerosols are dispersed in different environments, to forecasting the spread of the virus. As a Department of Energy national security laboratory with expertise in bioassay, fluid dynamics, and agent-based computer modeling, we were able to quickly pivot our focus to answer those questions. We have also answered questions about how to best store and transport testing kits, how the variants mutate, how different mitigation strategies impact school reopenings, and how to prioritize certain populations for vaccination to maximize the benefits. We continue to answer these questions and others.

Part of the reason national laboratories are called on to answer these questions is our computing power. At Los Alamos, we’ve been able to harness this power to forecast disease transmission rates and predict outcomes based on various mitigation strategies.

For example, epidemiological models developed at Los Alamos over the past 15 years were put to work simulating the actions and interactions of individual or collective groups to analyze and forecast the spread of the disease, and to assess the impact of mitigation strategies. Think of it as a life-simulation video game, creating a virtual city populated with virtual citizens who can be assigned ages, incomes, children who attend school, and jobs that take them through the community – all of it based on information pulled from sources such as the U.S. Census Bureau’s decennial census.

In addition to supercomputers, the national labs were called on for their diverse expertise in a broad range of scientific fields. For example, our expertise in weapons fluid dynamics provided insights into developing better ventilators to treat critical COVID-19 patients. And plume modeling that stems from our work mapping the travel path of potentially harmful gases and chemicals was utilized to understand how COVID-19 droplet plumes travel.

The result of all these nationwide endeavors was a host of tools and knowledge that decision makers could use at the state and national levels to address the challenges of COVID-19 head-on. But in order to effectively tackle the next challenge the nation may face, it is important to establish a consistent pipeline that integrates the expertise of academia, industry, and government to provide decision makers with the scientific answers they need before and during a crisis.

Now is the time, while interest and momentum are high, to take the steps to ensure that we establish a bridge between the R&D effort and the operational one so we can effectively answer the quick-turnaround technical questions when – not if – the next outbreak lands on American shores.


Patrick Fitch, Ph.D.,is the associate laboratory director for Chemical, Earth, and Life Sciences at Los Alamos National Laboratory, and also leads Los Alamos’ Special Office for COVID-19 Research and Development. Kirsten Taylor-McCabe, Ph.D., is the program manager for National Security and Defense, and Intelligence and Emerging Threats at Los Alamos National Laboratory.

J. Patrick Fitch, Ph.D.
J. Patrick Fitch, Ph.D.
J. Patrick Fitch, Ph.D., is Associate Laboratory Director at Los Alamos National Laboratory responsible for the Chemical, Earth and Life Sciences Directorate and the Special Office for COVID-19 R&D. He also leads the COVID-19 Testing Team for DOE’s National Virtual Biotechnology Laboratory. For more than a decade, he directed one of the nation’s largest maximum biocontainment laboratories (BSL-2, 3, and 4) and oversaw the National Biological Threat Characterization Center and the National Bioforensic Analysis Center performing thousands of analyses each year. Pat is a biodefense and infectious disease expert with related experience in computing, medical device design, and the human genome program. Pat has chaired and served on biodefense panels of the National Academies and served on the National Science Advisory Board for Biosecurity. He is a Fellow of AAAS and a senior member of IEEE. Pat earned his Ph.D. in Engineering from Purdue University. He may be reached at [email protected].

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